Aromatase: Contributions to Physiology and Disease in Women and Men.

@article{Blakemore2016AromataseCT,
  title={Aromatase: Contributions to Physiology and Disease in Women and Men.},
  author={Jennifer K. Blakemore and Frederick Naftolin},
  journal={Physiology},
  year={2016},
  volume={31 4},
  pages={258-69}
}
Aromatase (estrogen synthetase; EC 1.14.14.1) catalyzes the demethylation of androgens' carbon 19, producing phenolic 18-carbon estrogens. Aromatase is most widely known for its roles in reproduction and reproductive system diseases, and as a target for inhibitor therapy in estrogen-sensitive diseases including cancer, endometriosis, and leiomyoma (141, 143). However, all tissues contain estrogen receptor-expressing cells, the majority of genes have a complete or partial estrogen response… CONTINUE READING