Arming antibodies: prospects and challenges for immunoconjugates

  title={Arming antibodies: prospects and challenges for immunoconjugates},
  author={Anna M. Wu and Peter D. Senter},
  journal={Nature Biotechnology},
  • A. WuP. Senter
  • Published 1 September 2005
  • Biology, Chemistry
  • Nature Biotechnology
Immunoconjugates—monoclonal antibodies (mAbs) coupled to highly toxic agents, including radioisotopes and toxic drugs (ineffective when administered systemically alone)—are becoming a significant component of anticancer treatments. By combining the exquisite targeting specificity of mAbs with the enhanced tumor-killing power of toxic effector molecules, immunoconjugates permit sensitive discrimination between target and normal tissue, resulting in fewer toxic side effects than most conventional… 

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