Armed antibodies for cancer treatment: a promising tool in a changing era

@article{Danielli2014ArmedAF,
  title={Armed antibodies for cancer treatment: a promising tool in a changing era},
  author={Riccardo Danielli and Roberto Patuzzo and Pier Adelchi Ruffini and Andrea Maurichi and Leonardo Giovannoni and Giuliano Elia and Dario Neri and Mario Santinami},
  journal={Cancer Immunology, Immunotherapy},
  year={2014},
  volume={64},
  pages={113-121}
}
Advances in the understanding of tumor immunology and molecular biology of melanoma cells have favored a larger application of immunotherapy and targeted therapies in the clinic. Several selective mutant gene inhibitors and immunomodulating antibodies have been reported to improve overall survival or progression-free survival in metastatic melanoma patients. However, despite impressive initial responses, patients treated with selective inhibitors relapse quickly, and toxicities associated to… CONTINUE READING