Arlidin—a New Vasodilative Sympathomimetic Drug

  title={Arlidin—a New Vasodilative Sympathomimetic Drug},
  author={Louis M. Freedman},
  pages={52 - 58}
  • L. Freedman
  • Published 1 February 1955
  • Medicine, Chemistry
  • Angiology
blood pressure. (2) Desirable effects of vasodilating compounds would include increase in peripheral blood flow and a slight decrease in mean arterial pressure accompanied by an increase in cardiac output and in coronary circulation. Minimal burden on the heart, ease of dosage and elimination of side effects must also be considered as advantageous. Of all the epinephrine-like substances, Suprifen effects the greatest increase in cardiac output and the most extensive reduction in peripheral… 

Clinical pharmacology of vasodilating drugs

The human pharmacology of vasodilaiors and their total cardiovascular effect are reviewed, and laboratory studies are examined in the light of clinical observations, and the combined information serves as a basis for establishing indications for the use of these drugs.

Effects of buphenine (nylidrin) on the perfused mammalian eye

The studies suggest that the interaction of buphenine with retinal adrenergic receptors is not related to the vasculature present but to elements involved in information processing.

Effect of Nylidrin Hydrochloride On the Skin and Muscle Temperatures of Patients With Occlusive Arterial Disease of the Lower Extremities

The present study was undertaken to determine the effects of a new vasodilator substance, nylidrin hydrochloride,§§ on the skin and muscle temperatures of patients with occlusive arterial disease of the lower.

The Effects of Phenyl-2-Butyl Norsuprifen Hydrochloride On the Systemic and Coronary Hemodynamics and Metabolism of the Intact Dog*†

P phenyl-2butyl-norsuprifen hydrochloride (nylidrin) is used in clinical practice as a peripheral vasodilator and its effects upon the coronary vascular bed and myocardial metabolism are reported.


  • D. H. Klasson
  • Medicine
    Journal of the American Geriatrics Society
  • 1958
In treating these diseases, particularly if occlusive, it must be borne in mind that two main obstructive elements are affecting the circulation, one is the mechanical obstruction of the pathologic process itself and the other is the sympathetic vasospasm.

Therapy in Intermittent Claudication

Spasm, superimposed on local pathology, assumes an important role no matter how severe the local pathology may be and may be the occlusive factor, and its relief essential in therapy.

Arlidin: a clinical evaluation of a peripheral vasodilator with selective action on muscle vessels.

  • I. Stein
  • Medicine
    Annals of internal medicine
  • 1956
Excerpt A pressing need in the management of the chronic occlusive arterial diseases is an effective oral vasodilator to control the common presenting complaint of intermittent claudication. Many d...

Specific blockade of spasmogens by β‐receptor stimulation with nylidrin and isoprenaline

Nylidrin seems to be less potent but longer acting in its antispasmodic action than isoprenaline.

Time-Concentration Curves Over Calf and Foot of I131-Labeled Human Serum Albumin (Risa) After Intra-Arterial Injection

This study represents an attempt to develop a method to approximate the directional changes of blood flow separately in skin and muscle during the progressive course of vascular disease, and to evaluate therapy in patients with peripheral vascular insufhciency.



[Local anesthetic effects of sympathomimetic aralkyls of the adrenalin-benzedrine group. IV].

  • N. LudwigsK. Wiemers
  • Chemistry, Medicine
    Naunyn-Schmiedebergs Archiv fur experimentelle Pathologie und Pharmakologie
  • 1951
Die vonKulz entwickelten aralkylierten gefaserweiternden Sympathikomimetika besitzen im Quaddelversuch eine kraftige lokalanasthetische Wirkung auf den zweiten Benzolring zuruckzufuhren.

Die Blutzuckerwirksamkeit einiger neuer aralkylierter Sympathicomimetica

ZusammenfassungEs wurde an narkotisierten Hunden und Katzen die Blutzuckerwirksamkeit einer Reihe von Pharmaka aus der Adrenalin-Ephedrinreihe, die sich von den Ausgangssubstanzen durch Aralkylierung

[Vasodilative aralkyls of the adrenalin-benzedrine group. II. Analysis of the peripheral circulatory effects].

  • K. Wiemers
  • Medicine
    Naunyn-Schmiedebergs Archiv fur experimentelle Pathologie und Pharmakologie
  • 1951

[Vasodilative aralkyls of the adrenalin-benzedrine group. III. General pharmacologic investigations].

  • K. Wiemers
  • Medicine
    Naunyn-Schmiedebergs Archiv fur experimentelle Pathologie und Pharmakologie
  • 1951

Ergebn . Physiol . , 41 : 292 ,

  • 1939

Ztschr . Exper

  • 1952

Arch . exper

  • 1950

Structure et activite pharmacodynamique des medicaments du systeme nerveux vegatatif

  • 1948