Arl13b regulates ciliogenesis and the dynamic localization of Shh signaling proteins

@inproceedings{Larkins2011Arl13bRC,
  title={Arl13b regulates ciliogenesis and the dynamic localization of Shh signaling proteins},
  author={Christine E. Larkins and Gladys D. Gonzalez Aviles and Michael P. East and Richard A. Kahn and Tamara Caspary},
  booktitle={Molecular biology of the cell},
  year={2011}
}
Arl13b, a ciliary protein within the ADP-ribosylation factor family and Ras superfamily of GTPases, is required for ciliary structure but has poorly defined ciliary functions. In this paper, we further characterize the role of Arl13b in cilia by examining mutant cilia in vitro and determining the localization and dynamics of Arl13b within the cilium. Previously, we showed that mice lacking Arl13b have abnormal Sonic hedgehog (Shh) signaling; in this study, we show the dynamics of Shh signaling… CONTINUE READING

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