Ark floats gene therapy's boat, for now

@article{Osborne2008ArkFG,
  title={Ark floats gene therapy's boat, for now},
  author={Randy Osborne},
  journal={Nature Biotechnology},
  year={2008},
  volume={26},
  pages={1057-1059}
}
  • R. Osborne
  • Published 1 October 2008
  • Medicine
  • Nature Biotechnology

Ark's gene therapy stumbles at the finish line

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Two gene therapy drugs, Gendicine and Oncorine, have been marketed in China, and a number of upcoming gene therapy agents are under development for the treatment of head and neck cancer.

Viral vector-mediated gene transfer for CNS disease

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Although the majority of clinical trials have centered on gene replacement and neuroprotection approaches, the field is advancing in the direction of neuromodulation, gene silencing and other newer strategies.

Synthetic mRNA nanoparticle-mediated restoration of p53 tumor suppressor sensitizes p53-deficient cancers to mTOR inhibition

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Redox-sensitive mRNA nanoparticles help kill tumors by restoring p53 expression by delivering p53-mRNA in nanoparticles and indicate that restoration of tumor suppressors by the synthetic mRNA NP delivery strategy could be combined together with other therapies for potent combinatorial cancer treatment.

Regulatory and Scientific Advancements in Gene Therapy: State-of-the-Art of Clinical Applications and of the Supporting European Regulatory Framework

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The current European legal framework of ATMPs is reviewed, an overview of the clinical applications for approved and investigational GT MPs is provided, and critical challenges in the development of GTMPs are discussed.

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