Aristolochic acid-induced upper tract urothelial carcinoma in Taiwan: clinical characteristics and outcomes.

@article{Chen2013AristolochicAU,
  title={Aristolochic acid-induced upper tract urothelial carcinoma in Taiwan: clinical characteristics and outcomes.},
  author={Chung-Hsin Chen and Kathleen G Dickman and Chao-yuan Huang and Masaaki Moriya and C Y Shun and H J Tai and Kuo How Huang and S Wang and Yuan-Ju Lee and Arthur P. Grollman and Y K Pu},
  journal={International journal of cancer},
  year={2013},
  volume={133 1},
  pages={14-20}
}
Aristolochic acid (AA), a component of all Aristolochia-based herbal medicines, is a potent nephrotoxin and human carcinogen associated with upper urinary tract urothelial carcinoma (UUC). To investigate the clinical and pathological characteristics of AA-induced UUC, this study included 152 UUC patients, 93 of whom had been exposed to AA based on the presence of aristolactam-DNA adducts in the renal cortex. Gene sequencing was used to identify tumors with A:T-to-T:A transversions in TP53, a… CONTINUE READING
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