Aripiprazole monotherapy in the treatment of acute bipolar I mania: a randomized, double-blind, placebo- and lithium-controlled study.

@article{Keck2009AripiprazoleMI,
  title={Aripiprazole monotherapy in the treatment of acute bipolar I mania: a randomized, double-blind, placebo- and lithium-controlled study.},
  author={Paul E. Keck and Paul J. Orsulak and Andrew J. Cutler and Raymond Sanchez and Anne F. Torbeyns and Ronald N. Marcus and Robert D. McQuade and William H. Carson},
  journal={Journal of affective disorders},
  year={2009},
  volume={112 1-3},
  pages={36-49}
}
OBJECTIVES To evaluate the efficacy and safety of aripiprazole as acute and maintenance of effect monotherapy for acute bipolar mania. METHODS Patients with acute bipolar I mania (DSM-IV-TR: YMRS > or =20), manic or mixed (with or without psychotic features) were randomized to double-blind aripiprazole (15-30 mg/day; n=155), placebo (n=165) or lithium (900-1500 mg/day; n=160) (1:1:1) for 3 weeks. Aripiprazole- and lithium-treated patients remained on blinded treatment for 9 additional weeks… CONTINUE READING

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