Aripiprazole has Functionally Selective Actions at Dopamine D2 Receptor-Mediated Signaling Pathways

@article{Urban2007AripiprazoleHF,
  title={Aripiprazole has Functionally Selective Actions at Dopamine D2 Receptor-Mediated Signaling Pathways},
  author={Jonathan D. Urban and Gabriel A. Vargas and Mark Zastrow and Richard B. Mailman},
  journal={Neuropsychopharmacology},
  year={2007},
  volume={32},
  pages={67-77}
}
Aripiprazole is a unique atypical antipsychotic drug with an excellent side-effect profile presumed, in part, to be due to lack of typical D2 dopamine receptor antagonist properties. Whether aripiprazole is a typical D2 partial agonist, or a functionally selective D2 ligand, remains controversial (eg D2-mediated inhibition of adenylate cyclase is system dependent; aripiprazole antagonizes D2 receptor-mediated G-protein-coupled inwardly rectifying potassium channels and guanosine triphosphate… 

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