Aripiprazole differentially regulates the expression of Gad67 and γ-aminobutyric acid transporters in rat brain

@article{Peselmann2012AripiprazoleDR,
  title={Aripiprazole differentially regulates the expression of Gad67 and γ-aminobutyric acid transporters in rat brain},
  author={Nina Peselmann and Andrea Schmitt and Peter J. Gebicke-Haerter and Mathias Zink},
  journal={European Archives of Psychiatry and Clinical Neuroscience},
  year={2012},
  volume={263},
  pages={285-297}
}
The molecular etiology of schizophrenia comprises abnormal neurotransmission of the amino acid GABA (γ-aminobutyric acid). Neuropathological studies convincingly revealed reduced expression of glutamic acid decarboxylase (Gad67) in GABAergic interneurons. Several antipsychotics influence the expression of GABAergic genes, but aripiprazole (APZ), a partial dopaminergic and serotonergic receptor agonist, has not been involved into these studies so far. We treated Sprague–Dawley rats for 4 weeks… CONTINUE READING

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