Aripiprazole, A Novel Atypical Antipsychotic Drug with a Unique and Robust Pharmacology

@article{Shapiro2003AripiprazoleAN,
  title={Aripiprazole, A Novel Atypical Antipsychotic Drug with a Unique and Robust Pharmacology},
  author={David A. Shapiro and Sean M Renock and Elaine G Arrington and Louis A. Chiodo and Li-xin Liu and David R. Sibley and Bryan L. Roth and Richard B. Mailman},
  journal={Neuropsychopharmacology},
  year={2003},
  volume={28},
  pages={1400-1411}
}
Atypical antipsychotic drugs have revolutionized the treatment of schizophrenia and related disorders. The current clinically approved atypical antipsychotic drugs are characterized by having relatively low affinities for D2-dopamine receptors and relatively high affinities for 5-HT2A serotonin receptors (5-HT, 5-hydroxytryptamine (serotonin)). Aripiprazole (OPC-14597) is a novel atypical antipsychotic drug that is reported to be a high-affinity D2-dopamine receptor partial agonist. We now… 

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...

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