Aripiprazole, A Drug that Displays Partial Agonism and Functional 
Selectivity

@inproceedings{Tuplin2017AripiprazoleAD,
  title={Aripiprazole, A Drug that Displays Partial Agonism and Functional 
Selectivity},
  author={Erin W. Noye Tuplin and Matthew R. Holahan},
  booktitle={Current neuropharmacology},
  year={2017}
}
BACKGROUND The treatment of schizophrenia is challenging due to the wide range of symptoms (positive, negative, cognitive) associated with the disease. Typical antipsychotics that antagonize D2 receptors are effective in treating positive symptoms, but extrapyramidal side-effects (EPS) are a common occurrence. Atypical antipsychotics targeting 5-HT2A and D2 receptors are more effective at treating cognitive and negative symptoms compared to typical antipsychotics, but these drugs also result in… CONTINUE READING

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