Arimoclomol at dosages up to 300 mg/day is well tolerated and safe in amyotrophic lateral sclerosis.

@article{Cudkowicz2008ArimoclomolAD,
  title={Arimoclomol at dosages up to 300 mg/day is well tolerated and safe in amyotrophic lateral sclerosis.},
  author={Merit Ester Cudkowicz and Jeremy M. Shefner and Elizabeth Johnson Simpson and Daniela Grasso and Hong Yu and Hui Mao Zhang and Amy Shui and David Sch{\"o}nfeld and R. H. Brown and Scott Wieland and Jack R. Barber},
  journal={Muscle & nerve},
  year={2008},
  volume={38 1},
  pages={
          837-44
        }
}
Arimoclomol is an investigational drug for amyotrophic lateral sclerosis (ALS) that amplifies heat shock protein gene expression during cell stress. The objectives of the present study were to assess the safety, tolerability, and pharmacokinetics of arimoclomol in ALS. Eighty-four participants with ALS received arimoclomol at one of three oral doses (25, 50, or 100 mg three times daily) or placebo. The primary outcome measure was safety and tolerability. A subset of 44 participants provided… CONTINUE READING
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