Arimidex®: A potent and selective fourth-generation aromatase inhibitor

  title={Arimidex®: A potent and selective fourth-generation aromatase inhibitor},
  author={Paul V. Plourde and Martin C. Dyroff and Michael Alan Dukes},
  journal={Breast Cancer Research and Treatment},
Arimidex® is a potent and selective aromatase inhibitor undergoing evaluation as a treatment for postmenopausal women with advanced breast cancer. Studies to determine the pharmacology of Arimidex were conducted in both animals and humans. In animals, Arimidex was selective for the aromatase enzyme, elicited maximal activity at about 0.1 mg/kg, did not interfere with steroid hormones produced by the adrenal glands, and, at a dose of 1 mg/kg, had no detectable pharmacologic activity other than… CONTINUE READING
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Falkson HC: A study of Fadrazole, a new aromatase inhibitor, in postmenopausal women with advanced metastatic breast cancer

  • JI Raats, G Falkson
  • J Clin Oncol 10:111-116,
  • 1992
1 Excerpt

Misbin RI: Aminoglutethimide: review of pharmacology and clinical use

  • RJ Santen
  • Pharmacotherapy 11:95-120,
  • 1981
1 Excerpt

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