Argyrophilic grains of Braak: occurrence in dendrites of neurons containing hyperphosphorylated tau protein.

@article{Tolnay1998ArgyrophilicGO,
  title={Argyrophilic grains of Braak: occurrence in dendrites of neurons containing hyperphosphorylated tau protein.},
  author={Markus Tolnay and Claudia Mistl and Sabine Ipsen and Alphonse Probst},
  journal={Neuropathology and applied neurobiology},
  year={1998},
  volume={24 1},
  pages={53-9}
}
Braak's argyrophilic grains (ArGs) are spindle-shaped neuropil structures originally found in patients afflicted with adult onset dementia. We recently observed that tau protein is hyperphosphorylated in most nerve cells in areas rich in ArGs, suggesting that these grains may be a morphological expression of tau protein pathology in local neurons. The aim of this study was therefore to determine in three cases with ArGs whether grains are associated with individual neurons containing… CONTINUE READING
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