Argonaute proteins couple chromatin silencing to alternative splicing

@article{AmeyarZazoua2012ArgonautePC,
  title={Argonaute proteins couple chromatin silencing to alternative splicing},
  author={Maya Ameyar-Zazoua and Christophe Rachez and Mouloud Souidi and P. Huibers Robin and Lauriane Fritsch and RobertC. Young and N. Morozova and Romain Fenouil and Nicolas Descostes and Jean-Christophe Andrau and Jacques R. R. Mathieu and Ali Hamiche and Slimane Ait-Si-Ali and Christian Muchardt and Eric Batsch{\'e} and Annick Harel-Bellan},
  journal={Nature Structural &Molecular Biology},
  year={2012},
  volume={19},
  pages={998-1004}
}
Argonaute proteins play a major part in transcriptional gene silencing in many organisms, but their role in the nucleus of somatic mammalian cells remains elusive. Here, we have immunopurified human Argonaute-1 and Argonaute-2 (AGO1 and AGO2) chromatin-embedded proteins and found them associated with chromatin modifiers and, notably, with splicing factors. Using the CD44 gene as a model, we show that AGO1 and AGO2 facilitate spliceosome recruitment and modulate RNA polymerase II elongation rate… CONTINUE READING
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