Argonaute proteins: key players in RNA silencing

@article{Hutvagner2008ArgonautePK,
  title={Argonaute proteins: key players in RNA silencing},
  author={Gyorgy Hutvagner and Martin J Simard},
  journal={Nature Reviews Molecular Cell Biology},
  year={2008},
  volume={9},
  pages={22-32}
}
During the past decade, small non-coding RNAs have rapidly emerged as important contributors to gene regulation. To carry out their biological functions, these small RNAs require a unique class of proteins called Argonautes. The discovery and our comprehension of this highly conserved protein family is closely linked to the study of RNA-based gene silencing mechanisms. With their functional domains, Argonaute proteins can bind small non-coding RNAs and control protein synthesis, affect… CONTINUE READING

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