Argonaute HITS-CLIP decodes microRNA – mRNA interaction maps

@inproceedings{Chi2010ArgonauteHD,
  title={Argonaute HITS-CLIP decodes microRNA – mRNA interaction maps},
  author={Sung Wook Chi and Julie B Zang and Aldo Mele and Robert B Darnell},
  year={2010}
}
MicroRNAs (miRNAs) have critical roles in the regulation of gene expression; however, as miRNA activity requires base pairing with only 628 nucleotides of messenger RNA, predicting target mRNAs is a major challenge. Recently, high-throughput sequencing of RNAs isolated by crosslinking immunoprecipitation (HITS-CLIP) has identified functional protein–RNA… CONTINUE READING