Argonaute Divides Its RNA Guide into Domains with Distinct Functions and RNA-Binding Properties

@article{Wee2012ArgonauteDI,
  title={Argonaute Divides Its RNA Guide into Domains with Distinct Functions and RNA-Binding Properties},
  author={Liang Meng Wee and C. Fabi{\'a}n Flores-Jasso and William E. Salomon and Phillip D. Zamore},
  journal={Cell},
  year={2012},
  volume={152}
}
MicroRNAs (miRNAs) and small interfering RNAs (siRNAs) guide Argonaute proteins to silence mRNA expression. Argonaute binding alters the properties of an RNA guide, creating functional domains. We show that the domains established by Argonaute-the anchor, seed, central, 3' supplementary, and tail regions-have distinct biochemical properties that explain the differences between how animal miRNAs and siRNAs bind their targets. Extensive complementarity between an siRNA and its target slows the… CONTINUE READING
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