Argiotoxin636 inhibits NMDA-activated ion channels expressed in Xenopus oocytes

  title={Argiotoxin636 inhibits NMDA-activated ion channels expressed in Xenopus oocytes},
  author={A. Draguhn and W. Jahn and V. Witzemann},
  journal={Neuroscience Letters},
  • A. Draguhn, W. Jahn, V. Witzemann
  • Published 1991
  • Biology, Medicine
  • Neuroscience Letters
  • Argiotoxin636, a component of the spider venom of argiope species, was chemically synthesized together with a number of derivatives in order to analyse their blocking activity on mammalian glutamate receptors. Xenopus laevis oocytes injected with rat brain mRNA served as assay system. The results showed that argiotoxin636 had a higher affinity for N-methyl-D-aspartate (NMDA) than for kainate receptors, blocking the corresponding ion channels in a voltage-dependent manner. Modifications of the… CONTINUE READING
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