Arginyl-tRNA transferase activity as a maker of cellular aging in peripheral rat tissues

@article{Lamon1980ArginyltRNATA,
  title={Arginyl-tRNA transferase activity as a maker of cellular aging in peripheral rat tissues},
  author={Kim D. Lamon and Hideko Kaji},
  journal={Experimental Gerontology},
  year={1980},
  volume={15},
  pages={53-64}
}
  • K. Lamon, H. Kaji
  • Published 31 December 1980
  • Biology, Chemistry
  • Experimental Gerontology
Ablation of arginyl‐tRNA‐protein transferase in oligodendrocytes impairs central nervous system myelination
TLDR
It is demonstrated that Ate1 helps maintain proper OL differentiation and myelination in corpus callosum in vivo, and that protein arginylation plays an essential role in developmental myelinations.
Transfer ribonucleic acid dependent but ribosome-independent leucine incorporation into rat brain protein.
TLDR
An unusual type of posttranslational modification has been observed in a rat brain in vitro system and it is proposed that an ester bond is formed between the leucine and the side chain of a serine, threonine, or tyrosine in the acceptor protein.
Activity patterns of aminoacyl-tRNA synthetases, tRNA methylases, arginyltransferase and tubulin: tyrosine ligase during development and ageing of Caenorhabditis elegans.
TLDR
The results are consistent with the idea of a modulation of protein synthesis and other cellular processes by quantitative activity changes during development and ageing.
Biochemical analysis of protein arginylation.
Protein Arginylation, a Global Biological Regulator that Targets Actin Cytoskeleton and the Muscle
TLDR
An overview of the studies of protein arginylation that led to the discovery of its major role in the muscle is presented, and follow up studies strongly suggests that arkinylation constitutes a novel biological regulator of contractility.
Posttranslational arginylation as a global biological regulator.
Protein Arginylation: Over 50 Years of Discovery.
  • A. Kashina
  • Biology, Chemistry
    Methods in molecular biology
  • 2015
TLDR
This chapter contains an overview of all the major milestones in the protein arginylation field, from its original discovery in 1963 to this day.
Heat stress induced arginylation of HuR promotes alternative polyadenylation of Hsp70.3 by regulating HuR stability and RNA binding
TLDR
In conclusion, arginylation dependent modifications of HuR maintained its cellular homeostasis, and promoted APA of Hsp70.3 pre-mRNA, during early HS response.
...
...

References

SHOWING 1-10 OF 20 REFERENCES
Amino-terminal arginylation of chromosomal proteins by arginyl-tRNA.
  • H. Kaji
  • Biology, Chemistry
    Biochemistry
  • 1976
TLDR
Observations suggest that aminoacyl-transferase may function in the modification of chromosomal proteins and that modification of chromatin may alter the regulatory mechanisms of cellular functions.
Enzymatic modification of proteins. V. Protein acceptor specificity in the arginine-transfer reaction.
  • R. Soffer
  • Biology, Chemistry
    The Journal of biological chemistry
  • 1971
TLDR
The results indicate that the arginine-transfer reaction is highly specific with respect to protein acceptors and that this specificity is based on the presence of aspartic acid or glutamic acid at the NH2 termini.
Occurrence of arginyl-tRNA: protein arginyl transferase in baker's yeast.
Enzymatic ADP-ribosylation of proteins and regulation of cellular activity.
Enzymatic modification of proteins. II. Purification and properties of the arginyl transfer ribonucleic acid-protein transferase from rabbit liver cytoplasm.
  • R. Soffer
  • Biology, Chemistry
    The Journal of biological chemistry
  • 1970
Abstract The arginyl transfer ribonucleic acid-protein transferase has been purified nearly 7000-fold from the supernatant fraction of rabbit liver cytoplasm by a procedure including ammonium sulfate
Arginyl-tRNA-protein transferase in eucaryotic protists.
  • R. Soffer, C. Deutch
  • Biology, Chemistry
    Biochemical and biophysical research communications
  • 1975
Enzymatic arginylation of beta-melanocyte-stimulating hormone and of angiotensin II.
  • R. Soffer
  • Biology, Chemistry
    The Journal of biological chemistry
  • 1975
...
...