Arginyl residues: anion recognition sites in enzymes.

@article{Riordan1977ArginylRA,
  title={Arginyl residues: anion recognition sites in enzymes.},
  author={J. F. Riordan and K D McElvany and Charles L Borders},
  journal={Science},
  year={1977},
  volume={195 4281},
  pages={884-6}
}
Chemical modification with 2,3-butanedione in borate buffer indicates that nine of ten glycolytic enzymes studied contain arginyl residues at their active sites. Fructose-1,6-diphosphatase also has arginines at its binding site for the allosteric inhibitor, adenosine monophosphate. These and other data suggest that, as a general rule, enzymes acting on anionic substrates or cofactors will probably contain arginyl residues as components of their ligand binding sites. This could account in part… CONTINUE READING