Argininosuccinate synthetase overexpression in vascular smooth muscle cells potentiates immunostimulant-induced NO production.

@article{Xie1997ArgininosuccinateSO,
  title={Argininosuccinate synthetase overexpression in vascular smooth muscle cells potentiates immunostimulant-induced NO production.},
  author={Linjun Xie and Steven S. Gross},
  journal={The Journal of biological chemistry},
  year={1997},
  volume={272 26},
  pages={16624-30}
}
Immunostimulants trigger vascular smooth muscle cells (VSMC) to express both the inducible isoform of NO synthase (iNOS) and argininosuccinate synthetase (AS). With constitutively expressed argininosuccinate lyase (AL), AS confers cells with an Arg/Cit cycle that can sustain NO production via continuous regeneration of the NOS substrate, L-arginine (Arg), from the NOS coproduct, L-citrulline (Cit). To assess whether NO synthesis can be rate-limited by Arg recycling, we tested whether AS… CONTINUE READING
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