Argininosuccinate synthetase is a functional target for a snake venom anti-hypertensive peptide: role in arginine and nitric oxide production.

@article{Guerreiro2009ArgininosuccinateSI,
  title={Argininosuccinate synthetase is a functional target for a snake venom anti-hypertensive peptide: role in arginine and nitric oxide production.},
  author={Juliano Rodrigo Guerreiro and Claudiana Lameu and Eduardo Filipe Oliveira and Cl{\'e}cio Fernando Klitzke and Robson Melo and Edlaine Linares and Ohara Augusto and Jay William Fox and Ivo Lebrun and Solange Maria de Toledo Serrano and Antonio Carlos Martins de Camargo},
  journal={The Journal of biological chemistry},
  year={2009},
  volume={284 30},
  pages={20022-33}
}
Bj-BPP-10c is a bioactive proline-rich decapeptide, part of the C-type natriuretic peptide precursor, expressed in the brain and in the venom gland of Bothrops jararaca. We recently showed that Bj-BPP-10c displays a strong, sustained anti-hypertensive effect in spontaneous hypertensive rats (SHR), without causing any effect in normotensive rats, by a pharmacological effect independent of angiotensin-converting enzyme inhibition. Therefore, we hypothesized that another mechanism should be… CONTINUE READING

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