Argininosuccinate synthetase from the urea cycle to the citrulline-NO cycle.

  title={Argininosuccinate synthetase from the urea cycle to the citrulline-NO cycle.},
  author={Annie S Husson and Carole G Brasse-Lagnel and Alain Fairand and Sylvie Renouf and Alain M Lavoinne},
  journal={European journal of biochemistry},
  volume={270 9},
Argininosuccinate synthetase (ASS, EC catalyses the condensation of citrulline and aspartate to form argininosuccinate, the immediate precursor of arginine. First identified in the liver as the limiting enzyme of the urea cycle, ASS is now recognized as a ubiquitous enzyme in mammalian tissues. Indeed, discovery of the citrulline-NO cycle has increased interest in this enzyme that was found to represent a potential limiting step in NO synthesis. Depending on arginine utilization… CONTINUE READING
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