Argininosuccinate Synthase 1 is a Metabolic Regulator of Colorectal Cancer Pathogenicity.

@article{Bateman2017ArgininosuccinateS1,
  title={Argininosuccinate Synthase 1 is a Metabolic Regulator of Colorectal Cancer Pathogenicity.},
  author={Leslie A. Bateman and Wan-Min Ku and Martin J. Heslin and C M Contreras and Christine F. Skibola and Daniel K. Nomura},
  journal={ACS chemical biology},
  year={2017},
  volume={12 4},
  pages={
          905-911
        }
}
Like many cancer types, colorectal cancers have dysregulated metabolism that promotes their pathogenic features. In this study, we used the activity-based protein profiling chemoproteomic platform to profile cysteine-reactive metabolic enzymes that are upregulated in primary human colorectal tumors. We identified argininosuccinate synthase 1 (ASS1) as an upregulated target in primary human colorectal tumors and show that pharmacological inhibition or genetic ablation of ASS1 impairs colorectal… 
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