Arginine vasopressin-induced sensitization in brain: facilitated inositol phosphate production without changes in receptor number.

@article{Poulin1993ArginineVS,
  title={Arginine vasopressin-induced sensitization in brain: facilitated inositol phosphate production without changes in receptor number.},
  author={Pierre Poulin and Quentin J Pittman},
  journal={Journal of neuroendocrinology},
  year={1993},
  volume={5 1},
  pages={23-31}
}
Arginine vasopressin (AVP) has been shown to have a unique sensitization effect whereby repeated injection of AVP into a lateral cerebral ventricle or a mediobasal region of the rat forebrain below the lateral septum and including the anterior hypothalamus referred to as the ventral septal area, causes enhanced motor responses to the ligand. To elucidate possible neuronal mechanisms responsible for AVP sensitization, 1) we determined the dose and the time required for the development and… CONTINUE READING