Arginine uptake and metabolism in cultured murine macrophages

  title={Arginine uptake and metabolism in cultured murine macrophages},
  author={Anwar R. Baydoun and Richard G. Bogle and Jeremy D. Pearson and Giovanni E. Mann},
  journal={Agents and Actions},
Transport ofl-arginine and nitrite production were examined in the murine macrophage cell line J774. Lipopolysaccharide (LPS) induced a dose- and time-dependent stimulation of nitrite production which was further increased in the presence of interferon-γ (INF-γ). Nitrite synthesis was dependent on extracellular arginine and inhibited in the presence ofl-lysine. Treatment of cells with LPS and IFN-γ caused a reduction in intracellularl-arginine concentration which was accompanied by increases in… CONTINUE READING

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