Arginine uptake and metabolism in cultured murine macrophages

@article{Baydoun1993ArginineUA,
  title={Arginine uptake and metabolism in cultured murine macrophages},
  author={Anwar R. Baydoun and Richard G. Bogle and Jeremy D. Pearson and Giovanni E. Mann},
  journal={Agents and Actions},
  year={1993},
  volume={38},
  pages={C127-C129}
}
Transport ofl-arginine and nitrite production were examined in the murine macrophage cell line J774. Lipopolysaccharide (LPS) induced a dose- and time-dependent stimulation of nitrite production which was further increased in the presence of interferon-γ (INF-γ). Nitrite synthesis was dependent on extracellular arginine and inhibited in the presence ofl-lysine. Treatment of cells with LPS and IFN-γ caused a reduction in intracellularl-arginine concentration which was accompanied by increases in… CONTINUE READING

From This Paper

Figures, tables, and topics from this paper.

Citations

Publications citing this paper.
Showing 1-8 of 8 extracted citations

Acute renal response to LPS: impaired arginine production and inducible nitric oxide synthase activity.

American journal of physiology. Regulatory, integrative and comparative physiology • 2006
View 1 Excerpt

References

Publications referenced by this paper.
Showing 1-7 of 7 references

Transport of L - arginine is increased in macrophages generating nitric oxide

A. R. Baydoun, S. Moncada, J. D. Pearson, G. E. Mann
Biochem . J . • 1992

Glucocorticoids inhibition the induction of NO synthase in culture murine macrophages

M. Radomski M. Di-Rosa, S. Moncada
Biochem . Biophys . Res . Commun . • 1990

Nitric oxide: a cytotoxic activated macrophage effector molecule.

Biochemical and biophysical research communications • 1988
View 1 Excerpt

Similar Papers

Loading similar papers…