Arginine transport through system y(+)L in cultured human fibroblasts: normal phenotype of cells from LPI subjects.

@article{Dallasta2000ArginineTT,
  title={Arginine transport through system y(+)L in cultured human fibroblasts: normal phenotype of cells from LPI subjects.},
  author={Valeria Dall'asta and Ovidio Bussolati and Roberto Sala and Bianca Maria Rotoli and Gianfranco Sebastio and Maria Pia Sperandeo and Generoso Andria and Gian Carlo Gazzola},
  journal={American journal of physiology. Cell physiology},
  year={2000},
  volume={279 6},
  pages={C1829-37}
}
In lysinuric protein intolerance (LPI), impaired transport of cationic amino acids in kidney and intestine is due to mutations of the SLC7A7 gene. To assess the functional consequences of the LPI defect in nonepithelial cells, we have characterized cationic amino acid (CAA) transport in human fibroblasts obtained from LPI patients and a normal subject. In both cell types the bidirectional fluxes of arginine are due to the additive contributions of two Na(+)-independent, transstimulated… CONTINUE READING
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