Arginine transport is augmented, through modulation of cationic amino acid transporter-1, in obstructive uropathy in rats.


BACKGROUND The decrease in glomerular filtration rate (GFR), which is characteristic of obstructive uropathy, was suggested to be associated with attenuated nitric oxide (NO) generation. Since availability of L-arginine, the sole precursor for NO, governs NO synthesis, we aimed to determine the role of glomerular arginine transport in rats subjected to 24 h… (More)
DOI: 10.1159/000139617

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