Arginine transport in human monocytic leukemia THP-1 cells during macrophage differentiation.

@article{Barilli2011ArginineTI,
  title={Arginine transport in human monocytic leukemia THP-1 cells during macrophage differentiation.},
  author={Amelia Barilli and Bianca Maria Rotoli and Rossana Visigalli and Ovidio Bussolati and Gian Carlo Gazzola and Valeria Dall'asta},
  journal={Journal of leukocyte biology},
  year={2011},
  volume={90 2},
  pages={293-303}
}
L-arginine metabolism in myeloid cells plays a central role in the processes of macrophage activation and in the regulation of immune responses. In this study, we investigated arginine transport activity and the expression of the related transporter genes during the differentiation of monocytes to macrophages. We show here that the induction of THP-1 monocyte differentiation by PMA markedly increases the expression of SLC7A7 mRNA and of y(+)LAT1 protein and consequently, the activity of system… CONTINUE READING

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