Arginine stimulates growth hormone secretion by suppressing endogenous somatostatin secretion.

@article{AlbaRoth1988ArginineSG,
  title={Arginine stimulates growth hormone secretion by suppressing endogenous somatostatin secretion.},
  author={J. Alba-Roth and O. M{\"u}ller and J. Schopohl and K. von Werder},
  journal={The Journal of clinical endocrinology and metabolism},
  year={1988},
  volume={67 6},
  pages={
          1186-9
        }
}
To determine how arginine (Arg) stimulates GH secretion, we investigated its interaction with GHRH in vivo and in vitro. Six normal men were studied on four occasions: 1) Arg-TRH, 30 g arginine were administered in 500 mL saline in 30 min, followed by an injection of 200 micrograms TRH; 2) GHRH-Arg-TRH, 100 micrograms GHRH-(1-44) were given iv as a bolus immediately before the Arg infusion, followed by 200 micrograms TRH, iv; 3) GHRH test, 100 micrograms GHRH were given as an iv bolus; and 4… Expand
The decrease in growth hormone (GH) response after repeated stimulation with GH-releasing hormone is partly caused by an elevation of somatostatin tonus.
TLDR
The decreased GH response to a second GHRH bolus may be partly due to an elevated hypothalamic somatostatin secretion, which can be suppressed by Arg, and it is suggested that the readily available GH pool in the human pituitary may be limited. Expand
Impaired inhibitory effects of somatostatin on growth hormone (GH)-releasing hormone stimulation of GH secretion after short term infusion.
TLDR
The desensitization to SriH inhibition of GH responses to GHRH after a 6-h SRIH infusion provides evidence of physiological consequences of SRIh receptor down-regulation, and the impaired GH responding to repeated G HRH stimulation are mediated at least in part by enhanced SRI h secretion, which appears independent of a beta-adrenergic mechanism. Expand
Arginine abolishes the inhibitory effect of glucose on the growth hormone response to growth hormone-releasing hormone in man.
TLDR
The results show that Arg abolishes the inhibitory effect of OG administration on the GHRH-induced GH response in man, suggesting that both acute hyperglycemia and Arg act at the hypothalamic level, stimulating and inhibiting, respectively, the release of somatostatin. Expand
Low doses of either intravenously or orally administered arginine are able to enhance growth hormone response to growth hormone releasing hormone in elderly subjects
TLDR
The results show that the GH response to GHRH in elderly subjects is enhanced even by low iv doses of arginine and by the orally administered amino acid, the lowest effective dose being 8 g, implying that the combined administration of G HRH and ARG may be a useful approach to restore the impaired function of the GH-IGF axis in aging. Expand
IGF-I does not affect the net increase in GH release in response to arginine.
TLDR
The findings suggest that the negative feedback effect of IGF-I on GH secretion is primarily mediated at the pituitary level and/or at the hypothalamus through a mechanism different from the stimulatory effect of arginine. Expand
Low dose orally administered arginine is able to enhance both basal and growth hormone-releasing hormone-induced growth hormone secretion in normal short children
TLDR
Results show that a low dose of orally administered ARG is able to enhance the GHRH-induced GH rise with the same extent of a high dose iv administer ARG in normal short children. Expand
Growth hormone (GH) responsiveness to combined administration of arginine and GH-releasing hormone does not vary with age in man.
TLDR
The results show that the somatotroph response to combined administration of ARG and GHRH does not vary with age, and suggests that an increased somatostatinergic activity may underlie the reduced GH secretion in normal aging. Expand
Insulin-induced hypoglycemia, l-dopa and arginine stimulate GH secretion through different mechanisms in man
TLDR
The results suggest that a suppression of SRIH release may be partially involved in the stimulatory mechanism of GH secretion by L-dopa, and that arginine suppresses S RIH release from the hypothalamus to cause GH secretion because SRIh suppresses TSH secretion. Expand
Endogenous somatostatin is critical in regulating the acute effects of L-arginine on growth hormone and insulin release in mice.
TLDR
The hypothesis that the primary mechanism by which l-Arg acutely increases GH in vivo is by lowering hypothalamic SST input to the pituitary and not via direct pituitARY effects is supported. Expand
Galanin positively modulates prolactin secretion in normal women
TLDR
It is demonstrated that in normal women galanin enhances the PRL response to ARG and TRH but fails to modify that induced by dopamine receptor blockade with metoclopramide, and is unlikely that Galanin influences PRL secretion via inhibition of dopaminergic tone. Expand
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