Arginine residues as stabilizing elements in proteins.


Site-specific substitutions of arginine for lysine in the thermostable D-xylose isomerase (XI) from Actinoplanes missouriensis are shown to impart significant heat stability enhancement in the presence of sugar substrates most probably by interfering with nonenzymatic glycation. The same substitutions are also found to increase heat stability in the absence… (More)


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@article{Mrabet1992ArginineRA, title={Arginine residues as stabilizing elements in proteins.}, author={Nadir T. Mrabet and Arnaud Van den Broeck and I Van den brande and P Stanssens and Yves Laroche and Anne Marie Lambeir and G Matthijssens and Josh Jenkins and Mohamed Chiadmi and Herman van Tilbeurgh}, journal={Biochemistry}, year={1992}, volume={31 8}, pages={2239-53} }