Arginine physiology and its implication for wound healing

@article{Witte2003ArgininePA,
  title={Arginine physiology and its implication for wound healing},
  author={M. Witte and A. Barbul},
  journal={Wound Repair and Regeneration},
  year={2003},
  volume={11}
}
Arginine is a basic amino acid that plays several pivotal roles in cellular physiology. Like any amino acid, it is involved with protein synthesis, but it is also intimately involved with cell signaling through the production of nitric oxide and cell proliferation through its metabolism to ornithine and the other polyamines. Because of these multiple functions, arginine is an essential substrate for wound healing processes. Numerous studies have shown that arginine supplementation can lead to… Expand
Biological fate and clinical implications of arginine metabolism in tissue healing
TLDR
Subjects of interest in arginine metabolism are reviewed, with emphasis on the biochemistry of wound No production, relative NO synthase isoform activity in healing wounds, cellular contributions to NO production, and NO effects and mechanisms of action in wound healing. Expand
Arginine metabolism and wound healing
Wound healing is a complicated process needed to restore homeostasis in the body. The two arginine utilising pathways involved in wound healing are the inducible nitric oxide synthase (iNOS) toExpand
Arginine supplementation and wound healing.
TLDR
Well-designed clinical trials are required to determine whether arginine supplementation is effective in enhancing healing of acute and chronic wounds in humans and how muchArginine is recommended to meet metabolic needs during the phases of wound healing. Expand
5 Arginine, Citrulline, and Ornithine
Metabolism as well as function of the three amino acids, L-arginine, L-citrulline, and Lornithine, are closely intertwined and related to the homeostasis of nitric oxide at the tissue and cellularExpand
Advances and impact of arginine-based materials in wound healing.
  • Yang Zhou, Guiting Liu, Hai Huang, Jun Wu
  • Medicine
  • Journal of materials chemistry. B
  • 2021
TLDR
This review shows that arginine-based therapy can be separated in two categories: direct supplemental approaches of freeArginine, and indirect approaches based on arkinine derivatives in which modified arginin can be released after biodegradation. Expand
Evolutionary Roots of Arginase Expression and Regulation
  • J. Dzik
  • Biology, Medicine
  • Front. Immunol.
  • 2014
TLDR
The expression of arginase in lower animals can be induced by the presence of parasite antigens and TGF-β signals leading to collagen synthesis, which means that the main proteins, which are involved in regulation of tissue and organ differentiation in embryogenesis are produced by innate immunity. Expand
Arginase: an old enzyme with new tricks.
TLDR
The involvement of arginase in cardiovascular and nervous system dysfunction, and potential therapeutic interventions targeting excessArginase activity and expression are reviewed. Expand
Arginine metabolism and nutrition in growth, health and disease
TLDR
The results of both experimental and clinical studies indicate that Arg is a nutritionally essential amino acid (AA) for spermatogenesis, embryonic survival, fetal and neonatal growth, as well as maintenance of vascular tone and hemodynamics and novel and effective therapies for obesity, diabetes, and the metabolic syndrome. Expand
Role of Arginine and Omega-3 Fatty Acids in Wound Healing and Infection
TLDR
This combination of arginine and omega-3 polyunsaturated fatty acids in fish oil has been shown to affect outcomes involving wound healing and infections, and can also affect incidence and outcomes in cardiovascular disease, diabetes, organ transplant rejection, and other inflammatory conditions. Expand
Role of Arginine and Omega-3 Fatty Acids in Wound Healing and Infection.
TLDR
This combination of arginine and omega-3 polyunsaturated fatty acids in fish oil has been shown to affect outcomes involving wound healing and infections, and can also affect incidence and outcomes in cardiovascular disease, diabetes, organ transplant rejection, and other inflammatory conditions. Expand
...
1
2
3
4
5
...

References

SHOWING 1-10 OF 58 REFERENCES
Role of nitric oxide in wound repair.
TLDR
What is known about the role of NO in wound healing and the exact mechanisms of action of NO on wound healing parameters are still unknown are summarized. Expand
Temporal expression of different pathways of 1-arginine metabolism in healing wounds.
TLDR
The results indicate that the OAD pathway is expressed in this model predominantly during the early, polymorphonuclear leukocyte-predominant, phase of repair, and the reactive nitrogen intermediates resulting from the metabolism of arginine may mediate some of the events characteristic of early inflammation. Expand
Effect of supplemental ornithine on wound healing.
TLDR
The results from this study demonstrate that ornithine supplementation enhances wound healing in both WT and KO mice, and suggests that Ornithine's effect on wound healing is independent of the iNOS pathway. Expand
Arginine metabolism in wounds.
TLDR
The findings and the known metabolic fates of the products of arginase and arginine deiminase in the cellular populations of the wound suggest the possibility of cooperativity among cells for the production of substrates for collagen synthesis. Expand
Wound healing and thymotropic effects of arginine: a pituitary mechanism of action.
TLDR
It is concluded that an intact hypothalamic-pituitary axis is necessary for these beneficial effects of supplemental ARG-HCl given wounded rats. Expand
Regulation of macrophage functions by L-arginine
TLDR
The marked effects of L-arginine availability on macrophage functions, together with the knowledge that these cells modify the extracellular arginine concentration in sites of inflammation through arginase, provide evidence for an autoregulatory mechanism of macrophages activation. Expand
Arginine enhances wound healing and lymphocyte immune responses in humans.
TLDR
Assessment of the effect of oral arginine supplementation on human collagen synthesis and T-cell function and lymphocyte mitogenesis in response to phytohemagglutinin and concanavalin A suggests thatArginine may be of clinical benefit in improving wound healing and immune responses. Expand
Nitric oxide, an autocrine regulator of wound fibroblast synthetic function.
TLDR
The data show that WF are phenotypically altered during the healing process to synthesize NO, which, in turn, regulates their collagen synthetic and contractile activities. Expand
Nitric oxide regulates wound healing.
TLDR
The data suggest that nitric oxide synthesis is critical to wound collagen accumulation and acquisition of mechanical strength. Expand
Arginine: an essential amino acid for injured rats.
TLDR
It is concluded that arginine has two roles in wounded animals: it is essential for the synthesis of the increased amounts of reparative collagen required for wound healing, and it decreases some of the negative aspects of the metabolic responses to injury. Expand
...
1
2
3
4
5
...