Arginine-nitric oxide-polyamine metabolism in periodontal disease.

  title={Arginine-nitric oxide-polyamine metabolism in periodontal disease.},
  author={Leyla Ozer and Serenay Elgun and Burcu Ozdemir and Beste Pervane and Nurdan Ozmeriç},
  journal={Journal of periodontology},
  volume={82 2},
BACKGROUND Arginine is converted to nitric oxide (NO) via NO synthase and to ornithine via arginase. Ornithine decarboxylase (ODC) catalyzes the conversion of ornithine to polyamines. Arginase can inhibit NO production, and NO can inhibit ODC activity as part of an early inflammatory response. This study examines the arginine-NO-polyamine pathway alteration in saliva and gingival biopsy samples of patients with gingivitis or periodontitis and healthy controls and evaluates the response to… CONTINUE READING


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