Arginine methylation regulates telomere length and stability.

@article{Mitchell2009ArginineMR,
  title={Arginine methylation regulates telomere length and stability.},
  author={Taylor R. H. Mitchell and Kimberly Glenfield and Kajaparan Jeyanthan and Xu-Dong Zhu},
  journal={Molecular and cellular biology},
  year={2009},
  volume={29 18},
  pages={
          4918-34
        }
}
TRF2, a component of the shelterin complex, functions to protect telomeres. TRF2 contains an N-terminal basic domain rich in glycines and arginines, similar to the GAR motif that is methylated by protein arginine methyltransferases. However, whether arginine methylation regulates TRF2 function has not been determined. Here we report that amino acid substitutions of arginines with lysines in the basic domain of TRF2 induce telomere dysfunction-induced focus formation, leading to induction of… CONTINUE READING

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