Arginine methylation modulates autophagic degradation of PGL granules in C. elegans.

@article{Li2013ArginineMM,
  title={Arginine methylation modulates autophagic degradation of PGL granules in C. elegans.},
  author={Sihui Li and Peiguo Yang and Erming Tian and Hong Zhang},
  journal={Molecular cell},
  year={2013},
  volume={52 3},
  pages={
          421-33
        }
}
The selective degradation of intracellular components by autophagy involves sequential interactions of the cargo with a receptor, which also binds the autophagosomal protein Atg8 and a scaffold protein. Here, we demonstrated that mutations in C. elegans epg-11, which encodes an arginine methyltransferase homologous to PRMT1, cause the defective removal of PGL-1 and PGL-3 (cargo)-SEPA-1 (receptor) complexes, known as PGL granules, from somatic cells during embryogenesis. Autophagic degradation… CONTINUE READING
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