Arginine methylation-dependent regulation of ASK1 signaling by PRMT1

  title={Arginine methylation-dependent regulation of ASK1 signaling by PRMT1},
  author={J Cho and M-K Lee and Kyoung Wan Yoon and J Lee and Seok-Goo Cho and E Choi},
  journal={Cell Death and Differentiation},
Protein arginine methylation, catalyzed by protein arginine methyltransferases (PRMTs), is implicated in modulation of cellular processes including gene transcription. The role of PRMTs in the regulation of intracellular signaling pathways has remained obscure, however. We now show that PRMT1 methylates apoptosis signal-regulating kinase 1 (ASK1) at arginine residues 78 and 80 and thereby negatively regulates ASK1 signaling. PRMT1-mediated ASK1 methylation attenuated the H2O2-induced… CONTINUE READING
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