Arginine methylation catalyzed by PRMT1 is required for B cell activation and differentiation

@inproceedings{Infantino2017ArginineMC,
  title={Arginine methylation catalyzed by PRMT1 is required for B cell activation and differentiation},
  author={Simona Infantino and Amanda Light and Kristy O'Donnell and Vanessa L. Bryant and Danielle T Avery and Michael Elliott and Stuart G Tangye and Gabrielle T. Belz and Fabienne Mackay and St{\'e}phane Richard and David M Tarlinton},
  booktitle={Nature Communications},
  year={2017}
}
Arginine methylation catalyzed by protein arginine methyltransferases (PRMT) is a common post-translational modification in mammalian cells, regulating many important functions including cell signalling, proliferation and differentiation. Here we show the role of PRMT1 in B-cell activation and differentiation. PRMT1 expression and activity in human and mouse peripheral B cells increases in response to in vitro or in vivo activation. Deletion of the Prmt1 gene in mature B cells establishes that… CONTINUE READING