Arginine-enriched solution induces a marked increase in muscle glutamine concentration and enhances muscle protein synthesis in tumor-bearing rats.

@article{Oka1994ArginineenrichedSI,
  title={Arginine-enriched solution induces a marked increase in muscle glutamine concentration and enhances muscle protein synthesis in tumor-bearing rats.},
  author={Tetsuo Oka and Kazuo Ohwada and Mitsuhiro Nagao and Kenji Kitazato and Yasuo Kishino},
  journal={JPEN. Journal of parenteral and enteral nutrition},
  year={1994},
  volume={18 6},
  pages={
          491-6
        }
}
Using a transplantable Yoshida sarcoma in a rat model of total parenteral nutrition (TPN), we measured the effectiveness of an arginine-enriched amino acid solution (AI-82) on muscle glutamine concentration and muscle protein synthesis compared with that of a conventional amino acid solution (Proteamin12). After tumor-bearing rats had been given one of two isocaloric TPN regimens for 6 days, [15N]glycine (99 atom %) containing TPN solution was infused into animals at a constant rate of 8 mg of… CONTINUE READING