Arginine deprivation as a new treatment strategy for head and neck cancer.

OBJECTIVES Arginine is a nonessential amino acid which can regulate tumor growth. Argininosuccinate synthetase (ASS) is the rate-limiting enzyme for de novo arginine production. The expression pattern of ASS and the feasibility of arginine deprivation therapy in head and neck cancer have not been investigated. MATERIALS AND METHODS The growth-inhibitory… CONTINUE READING