Arginine deiminase modulates endothelial tip cells via excessive synthesis of reactive oxygen species.

@article{Zhuo2011ArginineDM,
  title={Arginine deiminase modulates endothelial tip cells via excessive synthesis of reactive oxygen species.},
  author={Wei Zhuo and Xiaoming Song and Haochen Zhou and Yongzhang Luo},
  journal={Biochemical Society transactions},
  year={2011},
  volume={39 5},
  pages={
          1376-81, suppl 2 p following 1382
        }
}
ADI (arginine deiminase), an enzyme that hydrolyses arginine, has been reported as an anti-angiogenesis agent. However, its molecular mechanism is unclear. We have demonstrated for the first time that ADI modulates the angiogenic activity of endothelial tip cells. By arginine depletion, ADI disturbs actin filament in endothelial tip cells, causing disordered migratory direction and decreased migration ability. Furthermore, ADI induces excessive synthesis of ROS (reactive oxygen species), and… 
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