Arginine degradation in developing porcine enterocytes.

@article{Wu1996ArginineDI,
  title={Arginine degradation in developing porcine enterocytes.},
  author={G. Y. Wu and Darrell A. Knabe and Nick E. Flynn and Wei Yan and Sean P. Flynn},
  journal={The American journal of physiology},
  year={1996},
  volume={271 5 Pt 1},
  pages={
          G913-9
        }
}
  • G. Wu, D. Knabe, S. Flynn
  • Published 1 November 1996
  • Biology, Medicine
  • The American journal of physiology
Arginine degradation was quantified in enterocytes of 0-day-old (newborn) and 4- to 21-day-old suckling pigs and 29- to 58-day-old pigs weaned at 21 days of age. Cells were incubated at 37°C for 30 min in 2 ml Krebs bicarbonate buffer (pH 7.4) in the presence of or 2 mM L-[U- 14 C]arginine or 0.5 mM L-[U- 14 C]ornithine, with or without 2 mM N G -nitro-L-arginine (L-NNA), 10 mM L-valine, or 2 mM gabaculine. Arginine degradation to CO 2 , ornithine, or proline was negligible in enterocytes of… 
Arginine catabolism in lactating porcine mammary tissue.
TLDR
It is demonstrated for the first time that proline, ornithine, and urea were the major products of arginine catabolism via the arginase pathway in lactating porcine mammary tissue and provide a biochemical basis to explain a relative enrichment of proline but a relative deficiency of arkinine in sow's milk.
Arginine catabolism in lactating porcine mammary tissue 1 , 2
TLDR
Relatively small amounts of arginine were utilized for nitric oxide and citrulline synthase pathways, and proline, ornithine, urea, glutamate, glutamine, CO2 and polyamines were formed from arginin, accounting for 46, 31, 17, 2.3, 1.5, 0.22, and 0.30%, respectively, of the metabolized arginines.
Lactate inhibits citrulline and arginine synthesis from proline in pig enterocytes.
TLDR
It is demonstrated that lactate decreased intestinal synthesis of citrulline and arginine from proline via an inhibition of proline oxidase and provide a biochemical basis for explaining hyperprolinemia, hypocitrullinemia, and hypoargininemia in infants with hyperlactacidemia.
Lactate inhibits citrulline and arginine synthesis from proline in pig enterocytes.
TLDR
It is demonstrated that lactate decreased intestinal synthesis of citrulline and arginine from proline via an inhibition of proline oxidase and provide a biochemical basis for explaining hyperprolinemia, hypocitrullinemia, and hypoargininemia in infants with hyperlactacidemia.
Enhanced intestinal synthesis of polyamines from proline in cortisol-treated piglets.
TLDR
It is indicated that an increase in plasma cortisol concentrations stimulates intestinal polyamines synthesis via a glucocorticoid receptor-mediated mechanism and that proline is a major source of ornithine for intestinal polyamine synthesis in suckling neonates.
Regulation of protein synthesis in porcine mammary epithelial cells by l-valine
TLDR
The critical role of l-valine is established in enhancing PMEC growth and milk protein synthesis possibly by regulating the mTOR and Ras/ERK signaling pathways.
Compartmentation and kinetics of urea cycle enzymes in porcine enterocytes.
  • P. Davis, G. Wu
  • Biology, Chemistry
    Comparative biochemistry and physiology. Part B, Biochemistry & molecular biology
  • 1998
Endogenous synthesis of arginine plays an important role in maintaining arginine homeostasis in postweaning growing pigs.
TLDR
An important role for endogenous synthesis of arginine in regulating arginines homeostasis in postweaning growing pigs is suggested, as previously shown in neonatal pigs.
Polyamine Synthesis from Proline in the Developing Porcine Placenta1
TLDR
Results indicate that proline is the major amino acid for polyamine synthesis in the porcine placenta and that the activity of this synthetic pathway is maximal during early pregnancy, when placental growth is most rapid.
Early weaning induces jejunal ornithine decarboxylase and cell proliferation in neonatal rats.
TLDR
The temporal sequence of increased ODC activity followed by increases in other growth variables suggests that the induction of O DC activity may act as an early marker of intestinal growth during early weaning.
...
...