Arginine and the Hofmeister Series: the role of ion-ion interactions in protein aggregation suppression.

@article{Schneider2011ArginineAT,
  title={Arginine and the Hofmeister Series: the role of ion-ion interactions in protein aggregation suppression.},
  author={Curtiss P. Schneider and Diwakar Shukla and Bernhardt L. Trout},
  journal={The journal of physical chemistry. B},
  year={2011},
  volume={115 22},
  pages={7447-58}
}
L-Arginine hydrochloride is a very important aggregation suppressor for which there has been much attention given regarding elucidating its mechanism of action. Little consideration, however, has been given toward other salt forms besides chloride, even though the counterion likely imparts a large influence per the Hofmeister Series. Here, we report an in depth analysis of the role the counterion plays in the aggregation suppression behavior of arginine. Consistent with the empirical Hofmeister… CONTINUE READING

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