Arginine and nitric oxide synthase: regulatory mechanisms and cardiovascular aspects.

@article{Lorin2014ArginineAN,
  title={Arginine and nitric oxide synthase: regulatory mechanisms and cardiovascular aspects.},
  author={Julie Lorin and Marianne Zeller and Jean-Claude Guilland and Yves Cottin and Catherine Vergely and Luc Rochette},
  journal={Molecular nutrition & food research},
  year={2014},
  volume={58 1},
  pages={101-16}
}
L-Arginine (L-Arg) is a conditionally essential amino acid in the human diet. The most common dietary sources of L-Arg are meat, poultry and fish. L-Arg is the precursor for the synthesis of nitric oxide (NO); a key signaling molecule via NO synthase (NOS). Endogenous NOS inhibitors such as asymmetric-dimethyl-L-Arg inhibit NO synthesis in vivo by competing with L-Arg at the active site of NOS. In addition, NOS possesses the ability to be "uncoupled" to produce superoxide anion instead of NO… CONTINUE READING