Arginine and arginase: endothelial NO synthase double crossed?

  title={Arginine and arginase: endothelial NO synthase double crossed?},
  author={Paul Michel Vanhoutte},
  journal={Circulation research},
  volume={102 8},
In a remarkable article published in this issue of Circulation Research, Ryoo et al1 propose endothelial arginase II as a novel target for the treatment of atherosclerosis. Actually, they already had done so 2 years ago, based on work mainly on cultured human aortic endothelial cells,2 which indeed appeared to provide an unexpected way to explain endothelial dysfunction in terms of NO production.3 This new road to endothelial dysfunction proposed that oxidized low-density lipoproteins (LDLs… CONTINUE READING
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