Arginine and Ornithine Supplementation Increases Growth Hormone and Insulin-Like Growth Factor-1 Serum Levels After Heavy-Resistance Exercise in Strength-Trained Athletes

@article{Zajc2010ArginineAO,
  title={Arginine and Ornithine Supplementation Increases Growth Hormone and Insulin-Like Growth Factor-1 Serum Levels After Heavy-Resistance Exercise in Strength-Trained Athletes},
  author={Adam Zając and Stanisław Poprzȩcki and Aleksandra Żebrowska and Małgorzata Chalimoniuk and J{\'o}zef Langfort},
  journal={Journal of Strength and Conditioning Research},
  year={2010},
  volume={24},
  pages={1082-1090}
}
This placebo-controlled double-blind study was designed to investigate the effect of arginine and ornithine (arg and orn) supplementation during 3-week heavy-resistance training on serum growth hormone/insulin-like growth factor-1/insulin-like growth factor-binding protein 3 (GH/IGF-1/IGFBP-3), testosterone, cortisol, and insulin levels in experienced strength-trained athletes. [] Key Method The subjects were randomly divided between a placebo group (n = 8) and the l-Arg/l-Orn-supplemented group (n = 9), and…

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References

SHOWING 1-10 OF 73 REFERENCES

Effects of exercise and alkalosis on serum insulin-like growth factor I and IGF-binding protein-3.

Concentrations of IGFBP3 were elevated above baseline at IP in both experimental and placebo conditions, and increases in IGF-I over resting conditions occurred with placebo conditions at 5 and 10 min postexercise and in the experimental condition at 5 min postExercise.

Low-dose amino acid supplementation: no effects on serum human growth hormone and insulin in male weightlifters.

The ergogenic value of low-dose oral amino acid supplementation in increasing hGH or insulin secretion seems questionable.

Insulin-like growth factor I exerts growth hormone- and insulin-like actions on human muscle protein metabolism.

  • D. Fryburg
  • Medicine, Biology
    The American journal of physiology
  • 1994
In conclusion, intra-arterial IGF-I exhibits growth hormone- like effects at all doses tested, whereas the insulin-like effects are observed at higher doses; these effects appear dependent on the route of administration.

Effect of protein supplementation during a 6-mo strength and conditioning program on insulin-like growth factor I and markers of bone turnover in young adults.

Protein supplementation during a strength and conditioning program resulted in changes in IGF-I concentrations, and serum bone alkaline phosphatase concentrations changed over time, which were greater in the protein group than in the carbohydrate group.

Effects of resistance training on insulin-like growth factor-I and IGF binding proteins.

Findings indicate that increased circulating IGF-I may, at least in part, mediate increases in strength that result from resistance training.

Growth hormone and testosterone interact positively to enhance protein and energy metabolism in hypopituitary men.

GH-induced increase of circulating IGF-I is augmented by T, which does not increase IGF- I in the absence of GH, but T exerted independent and additive effects on protein metabolism, F(ox) and REE.

Synergy of L-arginine and GHRP-2 stimulation of growth hormone in men and women: modulation by exercise.

It is inferred that gender strongly controls the relative but not absolute magnitude of A/G synergy both at rest and after exercise, and exercise is likely to induce release of both GHRH and somatostatin.

Overnight responses of the circulating IGF-I system after acute, heavy-resistance exercise.

The results from this study suggest that acute, heavy-resistance exercise can lead to alterations in the IGF-I system that can be detected in the systemic circulation.

Oral arginine attenuates the growth hormone response to resistance exercise.

The combined effect of arginine before exercise attenuates the GH response, and autonegative feedback possibly causes a refractory period such that when the two stimuli are presented there will be suppression of the somatotrope.

Responses of IGF-I to endogenous increases in growth hormone after heavy-resistance exercise.

Data demonstrate that a high-intensity bout of heavy-resistance exercise that increases circulating GH did not appear to affect IGF-I concentrations over a 24-h recovery period in recreationally strength-trained and healthy young men.
...