Arginine and Lysine Transporters Are Essential for Trypanosoma brucei

  title={Arginine and Lysine Transporters Are Essential for Trypanosoma brucei},
  author={Christoph Mathieu and Juan P. Mac{\^e}do and Daniel H{\"u}rlimann and Corina Wirdnam and Alexander C. Haindrich and Marianne Suter Grotemeyer and Amaia Gonz{\'a}lez-Salgado and Remo S. Schmidt and Ehud Inbar and Pascal M{\"a}ser and Peter B{\"u}tikofer and Dan Zilberstein and Doris Rentsch},
  booktitle={PloS one},
For Trypanosoma brucei arginine and lysine are essential amino acids and therefore have to be imported from the host. Heterologous expression in Saccharomyces cerevisiae mutants identified cationic amino acid transporters among members of the T. brucei AAAP (amino acid/auxin permease) family. TbAAT5-3 showed high affinity arginine uptake (Km 3.6 ± 0.4 μM) and high selectivity for L-arginine. L-arginine transport was reduced by a 10-times excess of L-arginine, homo-arginine, canavanine or… CONTINUE READING
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