Arginine and Citrulline and the Immune Response in Sepsis

@inproceedings{Wijnands2015ArginineAC,
  title={Arginine and Citrulline and the Immune Response in Sepsis},
  author={Karolina A.P. Wijnands and Tessy M.R. Castermans and Merel P.J. Hommen and Dennis M. Meesters and Martijn Poeze},
  booktitle={Nutrients},
  year={2015}
}
Arginine, a semi-essential amino acid is an important initiator of the immune response. Arginine serves as a precursor in several metabolic pathways in different organs. In the immune response, arginine metabolism and availability is determined by the nitric oxide synthases and the arginase enzymes, which convert arginine into nitric oxide (NO) and ornithine, respectively. Limitations in arginine availability during inflammatory conditions regulate macrophages and T-lymfocyte activation… CONTINUE READING
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