Arginine Starvation Impairs Mitochondrial Respiratory Function in ASS1-Deficient Breast Cancer Cells

@article{Qiu2014ArginineSI,
  title={Arginine Starvation Impairs Mitochondrial Respiratory Function in ASS1-Deficient Breast Cancer Cells},
  author={Fuming Qiu and Yun-Ru Chen and Xiyong Liu and Cheng-Ying Chu and Li-Jiuan Shen and J Xu and Shikha Gaur and Henry Jay Forman and Hang Zhang and Shu Zheng and Yun Yen and Junji Huang and H Kung and David Kong Ann},
  journal={Science Signaling},
  year={2014},
  volume={7},
  pages={ra31-ra31}
}
Autophagy is the principal catabolic response to nutrient starvation and is necessary to clear dysfunctional or damaged organelles, but excessive autophagy can be cytotoxic or cytostatic and contributes to cell death. Depending on the abundance of enzymes involved in molecule biosynthesis, cells can be dependent on uptake of exogenous nutrients to provide these molecules. Argininosuccinate synthetase 1 (ASS1) is a key enzyme in arginine biosynthesis, and its abundance is reduced in many solid… CONTINUE READING
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